Trial intelligence / Profile preview

Modified DEP Regimens for HLH

NCT06504030Phase 4Not yet recruiting

Sponsor
First Affiliated Hospital of Soochow University
Start
Aug 2024
Primary completion
Aug 2026
Modality
DNA Intercalators/Alkylators, Orthosteric Ligands
01

Overview

Phase 4, open-label, single-arm trial of doxorubicin, etoposide, methylprednisolone and ruxolitinib in hemophagocytic lymphohistiocytosis (HLH), sponsored by First Affiliated Hospital of Soochow University. Primary endpoints: Response rate of modified-DEP at 8 weeks and Incidence of Treatment-Emergent Adverse Events at 8 weeks. Planned start Aug 2024; status: not yet recruiting.

02

Drugs

doxorubicinetoposidemethylprednisoloneruxolitinib
03

Conditions

hemophagocytic lymphohistiocytosis (HLH)

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