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Lidocaine vs Fentanyl for Anesthesia Induction in Hypertensive Adults
NCT06557473Phase 4
Key facts
- Status
- Completed
- Start
- Apr 2023
- Primary completion
- May 2024
- Countries
- 1
- Sponsor
- Theodor Bilharz Research Institute
- Modality
- Small Molecules
- Conditions
- hypotension
01
Overview
Phase 4, randomised, double-blind trial of Lidocaine Hydrochloride Injection, without epinephrine in hypotension (2 arms), sponsored by Theodor Bilharz Research Institute. Primary endpoint: Mean Arterial Pressure. Started Apr 2023; status: completed.
02
Design
2 arms- Study design
- RandomizedDouble-blind
Lidocaine Group
Lidocaine 1.5 mg/kg + Propofol 2 mg/kg + Atracurium 0.5 mg
Fentanyl Group
Fentanyl 2 µg/kg + Propofol 2 mg/kg + Atracurium 0.5 mg
03
Who it enrols
Hypertensive adults (ASA II) aged 18-60 undergoing elective non-cardiac surgery, with controlled hypertension (>5 years duration). Excludes obese patients (BMI >= 35), uncontrolled hypertension, pregnancy, drug abuse, and difficult intubation.
04
Endpoints
Primary
Mean Arterial Pressure
Secondary
Number of hypotensive episodes
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