Trial intelligence / Profile preview

Phase 3 trial of rilvegostomig-based combinations versus trastuzumab + chemotherapy + pembrolizumab in HER2-positive gastric or gastroesophageal junction adenocarcinoma

NL-OMON60911Phase 3Recruiting

Sponsor
AstraZeneca
Start
Oct 2025
Modality
Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
Countries
1
01

Overview

Phase 3, randomised trial of rilvegostomig, trastuzumab deruxtecan, trastuzumab, pembrolizumab, fluorouracil and 3 more in gastric adenocarcinoma and gastroesophageal junction adenocarcinoma (3 arms), sponsored by AstraZeneca. Primary endpoints: Progression-free Survival and Overall Survival. Started Oct 2025; status: recruiting.

02

Drugs

rilvegostomigtrastuzumab deruxtecantrastuzumabpembrolizumabfluorouracil
03

Conditions

gastric adenocarcinomagastroesophageal junction adenocarcinoma

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