15N2-tofacitinib

15N2-tofacitinib is a stable isotope-labeled form of tofacitinib, in which two nitrogen atoms are replaced with the ^15N isotope. It is primarily used as an internal standard in bioanalytical assays (such as LC-MS/MS) for the quantification of tofacitinib in biological samples. Tofacitinib itself is a small molecule Janus kinase (JAK) inhibitor that modulates immune function by inhibiting JAK1 and JAK3, and to a lesser extent JAK2, thereby interfering with cytokine signaling involved in inflammatory and autoimmune diseases. The labeled version does not have therapeutic use but supports pharmacokinetic and drug metabolism studies.

Other names

15N2-tofacitinib