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BCD-021 + carboplatin + paclitaxel is a drug combination studied for the treatment of advanced non-squamous non-small cell lung cancer (NSCLC). BCD-021 is a biosimilar of bevacizumab (Avastin). This combination has demonstrated therapeutic equivalence to the reference Avastin + carboplatin + paclitaxel regimen. Clinical trials have shown comparable objective response rates (ORR), complete response rates, partial response rates, and safety profiles. The administration sequence is critical, with paclitaxel typically given before carboplatin to maximize efficacy due to sequence-dependent interactions.
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