Beni-Suef Univ. STAT-3/c-Src compound 7c

Beni-Suef Univ. STAT-3/c-Src compound 7c: sourced facts only. name: "Surprisingly, both derivatives 7c and 12d demonstrated more potent inhibitory activity (IC50 = 1.291 ± 0.055 and 0.844 ± 0.036 μM, sequentially) towards STAT-3 enzyme compared to the reference drug STAT3-IN-3 (IC50 = 2.1 ± 0.20 μM)."; target: "Surprisingly, both derivatives 7c and 12d demonstrated more potent inhibitory activity (IC50 = 1.291 ± 0.055 and 0.844 ± 0.036 μM, sequentially) towards STAT-3 enzyme compared to the reference drug STAT3-IN-3 (IC50 = 2.1 ± 0.20 μM)."; target: "Also, the pyrazoloquinazoline derivative 12d (IC50 = 0.268 ± 0.011 μM) showed highest inhibitory activity than the hydroxyimino derivative 7c (IC50 = 0.565 ± 0.024 μM) against c-Src enzyme compared to staurosporin (IC50 = 0.139 ± 0.006 μM) as reference drug."; developer: "Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt."