Drug intelligence / Profile preview

cyclophosphamide + dexamethasone + sulfasalazine

Development stage
Preclinical
Lead developer
Takeda
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Oral, Intravenous
01

Overview

This is a combination regimen consisting of three drugs—cyclophosphamide, dexamethasone, and sulfasalazine—each with distinct mechanisms of action. Cyclophosphamide is an alkylating agent used primarily as an antineoplastic and immunosuppressive drug; it interferes with DNA replication and cell division, leading to cytotoxic effects on rapidly dividing cells[2]. Dexamethasone is a synthetic glucocorticoid corticosteroid that exerts potent anti-inflammatory and immunosuppressive effects by modulating gene expression through the glucocorticoid receptor. Sulfasalazine is a disease-modifying antirheumatic drug (DMARD) with anti-inflammatory properties; it is metabolized into active components that reduce inflammation in conditions such as rheumatoid arthritis and inflammatory bowel disease[1][3]. While all three drugs are individually approved for various indications (e.g., cancer, autoimmune diseases), this specific triple combination does not have a unique brand name or established fixed-dose formulation but may be used off-label in complex autoimmune or inflammatory conditions where multiple pathways need to be targeted.

02

Targets

GR (Glucocorticoid receptor)DNA

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