cyclophosphamide + methylprednisolone + prednisone

This is a combination regimen of three drugs—cyclophosphamide, methylprednisolone, and prednisone—used primarily as an immunosuppressive and anti-inflammatory therapy in severe autoimmune diseases such as lupus nephritis and systemic vasculitis. Cyclophosphamide is an alkylating agent that suppresses the immune system by cross-linking DNA, leading to cell death in rapidly dividing cells including lymphocytes. Methylprednisolone and prednisone are synthetic glucocorticoid corticosteroids that reduce inflammation by inhibiting leukocyte migration and suppressing immune responses. This combination aims to maximize immunosuppression for disease control while balancing toxicity risks[1][4][5].

Other names

cyclophosphamide and steroidscyclophosphamide + steroids