Drug intelligence / Profile preview

econazole + triamcinolone

Development stage
Unknown
Lead developer
ACI Pharmaceuticals
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Topical
01

Overview

Econazole + triamcinolone is a topical combination drug consisting of two active ingredients: - **Econazole** is an imidazole antifungal agent that inhibits the synthesis of ergosterol in fungal cell membranes, leading to increased membrane permeability and cell death. It has broad-spectrum activity against dermatophytes (such as Trichophyton spp., Epidermophyton floccosum), yeasts (including Candida albicans), and some gram-positive bacteria. - **Triamcinolone** (usually as the acetonide ester) is a synthetic corticosteroid with anti-inflammatory, antipruritic, and anti-allergic properties. It works by inhibiting multiple inflammatory cytokines and suppressing both early and late phases of inflammation. This combination cream is indicated for the treatment of steroid-responsive inflammatory dermatomycoses with or without secondary bacterial infection. Common indications include eczematous mycoses, tinea pedis (athlete’s foot), tinea corporis (ringworm), tinea cruris (jock itch), psoriasis with superimposed fungal infection, intertrigo, diaper dermatitis complicated by fungi or bacteria sensitive to these agents[3][4][5][6].

Brand names
Ecoren TEconate PlusTriamazole
Other names
econazole/triamcinolonetriamcinolone acetonide econazole creameconazole nitrate + triamcinolone acetonide
02

Targets

CYP51A1 (Sterol 14α-demethylase)GR (Glucocorticoid receptor)PXR (Pregnane X receptor)

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