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ELN28

Development stage: Preclinical
Lead developer: Elasmogen

Overview

**ELN28** is an Elasmogen-developed, first-in-class dual-acting soloMER drug conjugate being developed for hidradenitis suppurativa. The conjugate binds and neutralizes soluble tumor necrosis factor alpha at inflamed tissue and uses a neutrophil elastase-cleavable linker to locally release the Janus kinase inhibitor tofacitinib, aiming to combine TNF alpha blockade with inflammation-site-restricted JAK inhibition while reducing systemic exposure to free tofacitinib. ([elasmogen.com](https://elasmogen.com/))

Targets

TNFA (Tumor necrosis factor alpha (soluble))JAK3 (Janus kinase 3)JAK1 (Janus kinase 1)JAK2 (Janus kinase 2)

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