Drug intelligence / Profile preview

fenfluramine analog

Development stage
Preclinical
Lead developer
UCB
Modality
Small Molecules
Administration
Oral
01

Overview

Fenfluramine analog is a small molecule serotonin (5-HT) releaser being developed by EQUULUS Therapeutics for the treatment of obesity and seizure disorders. Currently in the discovery phase, the drug is designed as an analog of fenfluramine, a known serotonergic agent. By acting as a serotonin releaser, the compound aims to modulate central nervous system pathways involved in appetite regulation and neuronal excitability, potentially offering a therapeutic option for metabolic and neurological conditions while aiming for an optimized safety profile compared to legacy compounds.

Other names
Fenfluramine Analog
02

Targets

SERT (Sodium-dependent serotonin transporter)HTR4 (5-Hydroxytryptamine receptor 4)HTR2A (Serotonin receptor 5-HT2A)HTR1D (5-hydroxytryptamine receptor 1D)SIGMAR1 (Sigma non-opioid intracellular receptor 1)HTR2C (5-hydroxytryptamine 2C receptor)

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