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GDC-0214
- Development stage
- Discontinued
- Lead developer
- Genentech
- Modality
- Small Molecules
- Administration
- Inhalation
01
Overview
GDC-0214 is a potent, selective small molecule inhibitor of Janus kinase 1 (JAK1) developed for inhaled administration as a potential treatment for asthma. The drug was designed to achieve targeted JAK1 inhibition in the lungs while minimizing systemic exposure and associated toxicity. By inhibiting JAK1, GDC-0214 blocks signaling pathways mediated by cytokines such as interleukin (IL)-4 and IL-13 that are implicated in the pathogenesis of asthma. Clinical studies demonstrated dose-dependent reductions in fractional exhaled nitric oxide (FeNO), a biomarker of airway inflammation dependent on JAK1-mediated pathways. The drug was developed by Genentech (a subsidiary of Roche) but its development for asthma has been discontinued after phase I trials.
- Other names
- GDC0214GDC-0214GDC 0214
02
Targets
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