Drug intelligence / Profile preview

Huaban Decoction

Development stage
Unknown
Lead developer
Longhua Hospital Shanghai University of Traditional Chinese Medicine
Administration
Oral
01

Overview

Huaban Decoction (Huaban Tang) is a Traditional Chinese Medicine (TCM) herbal formula primarily used to clear heat, detoxify, and cool the blood. In modern clinical research, it is being investigated for the prevention and treatment of radiation-induced lung injury (RILI) in patients with lung cancer receiving thoracic radiotherapy. The formula typically consists of ingredients such as Gypsum Fibrosum, Rhizoma Anemarrhenae, Radix Glycyrrhizae, Oryza Sativa, Cornu Bubali, and Radix Rehmanniae. It is hypothesized to work by modulating inflammatory cytokines (e.g., TNF-alpha, IL-6) and fibrotic signaling pathways (e.g., TGF-beta1) to protect lung parenchyma from radiation damage. It is currently being studied in Phase 2 clinical trials, often in combination with other formulas like Shenling Baizhu Powder, to improve clinical outcomes and quality of life for cancer patients.

Other names
Huaban TangHuabantang
02

Targets

RELA (Nuclear Factor Kappa B Subunit p65)IL-6 (Interleukin 6)TGFB1 (Transforming growth factor Beta-1 proprotein)NFKBIA (NFKB inhibitor alpha)

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