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levofloxacin + piperacillin + tazobactam
- Development stage
- Unknown
- Lead developer
- Pfizer
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
A combination antibiotic regimen consisting of levofloxacin (a fluoroquinolone) and piperacillin/tazobactam (a beta-lactam/beta-lactamase inhibitor combination). This regimen demonstrates synergistic activity against multidrug-resistant bacteria, particularly Pseudomonas aeruginosa. The combination leverages different mechanisms of action to enhance efficacy and potentially prevent the emergence of resistance. It is used primarily for serious infections where multidrug-resistant organisms are suspected.
- Brand names
- Zosyn (for piperacillin/tazobactam)Levaquin (for levofloxacin)
- Other names
- piperacillin-tazobactam plus levofloxacinpiperacillin/tazobactam and levofloxacin
02
Targets
Topo IV (Bacterial Topoisomerase IV)DNA gyraseβ-lactamasePBP (Penicillin-binding protein family)
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