M119102

M119102 is a topical formulation of tofacitinib, a Janus kinase (JAK) inhibitor, developed by Maruho Co., Ltd. for the treatment of alopecia areata. It is formulated as a 10% ointment for twice-daily application. Tofacitinib acts by inhibiting the Janus kinase family of enzymes, specifically JAK1, JAK2, and JAK3, which are critical components of the signaling pathways for various pro-inflammatory cytokines. In alopecia areata, these pathways drive the T-cell-mediated autoimmune destruction of hair follicles. By delivering the drug topically, M119102 aims to achieve high local drug concentrations in the scalp to suppress the inflammatory response and promote hair regrowth while minimizing the systemic exposure and associated side effects typically seen with oral JAK inhibitor therapy.

Other names

topical tofacitinibtofacitinib ointmenttofacitinib 10% ointment