Drug intelligence / Profile preview

Pepticom oral IL-17 peptide inhibitor

Development stage
Preclinical
Lead developer
Pepticom
Modality
Peptides
Administration
Oral
01

Overview

Pepticom is developing an AI-designed, orally administered peptide therapeutic targeting the IL-17 pathway for the treatment of plaque psoriasis. The program utilizes fully synthetic, small cyclic peptidomimetic inhibitors that target both IL-17A and IL-17F isoforms with nanomolar activity. These compounds are engineered for high stability and extended half-life using non-natural amino acids. By inhibiting IL-17-mediated inflammation, this drug aims to provide an oral alternative to existing injectable IL-17 blockers. The program is currently in the lead optimization phase, with a formal drug candidate expected to be announced in 2025.

Other names
Pepticom-IL-17-Peptide-oral-Plaque PsoriasisPepticom-IL17-Peptide-oral-Plaque PsoriasisPepticom-IL 17-Peptide-oral-Plaque PsoriasisPepticom oral IL-17 peptideAI-designed oral IL-17 peptide
02

Targets

IL17F (Interleukin 17F)IL-17A (Interleukin-17A)

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