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rAAV2-GFP
- Development stage
- Preclinical
- Modality
- Gene Therapies
- Administration
- Intravitreal, Intravenous, Intrathecal, Intratumoral
01
Overview
rAAV2-GFP is a recombinant adeno-associated virus serotype 2 (rAAV2) vector engineered to deliver and express the gene for green fluorescent protein (GFP). It is primarily utilized as a reporter or control vector in preclinical research and gene therapy development rather than as a therapeutic agent. The vector utilizes the AAV2 capsid to transduce various cell types, including neurons, retinal cells, and hepatocytes, allowing for the visualization and tracking of gene expression and cellular processes via GFP fluorescence. In research settings, it serves as a benchmark for evaluating transduction efficiency, viral genome integrity, and the impact of capsid impurities on functional potency. It is widely employed in studies related to neurodegenerative diseases, retinal disorders, and liver-directed gene delivery.
- Other names
- recombinant adeno-associated virus serotype 2-green fluorescent proteinAAV2-eGFPAAV-2-eGFPAAV 2-eGFP
02
Targets
HSPG (Basement membrane-specific heparan sulfate proteoglycan core protein (perlecan))αVβ5 (Integrin αVβ5)FGFR1 (Fibroblast growth factor receptor 1)
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