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RG6981
- Lead developer
- Roche
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous, Subcutaneous
01
Overview
RG6981 (formerly QX031N) is an investigational long-acting bispecific monoclonal antibody designed to simultaneously target and neutralize the epithelial alarmin cytokines thymic stromal lymphopoietin (TSLP) and interleukin-33 (IL-33). Originally developed by Qyuns Therapeutics and licensed globally to Roche in October 2025, RG6981 is engineered to suppress the upstream inflammatory cascades that drive chronic airway inflammation. By blocking both TSLP and IL-33, the therapy aims to provide a more comprehensive anti-inflammatory effect than single-target agents. It is currently in Phase I clinical development for the treatment of chronic obstructive pulmonary disease (COPD) and asthma.
02
Targets
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