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ZG005 + gecacitinib
- Development stage
- Phase 2
- Lead developer
- Suzhou Zelgen Biopharmaceuticals
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
- ZG005 + gecacitinib is an experimental combination of two drugs: ZG005, a bispecific antibody that simultaneously targets PD-1 (Programmed cell death protein 1) and TIGIT (T cell immunoreceptor with Ig and ITIM domains), and gecacitinib, a small molecule inhibitor of Janus kinases (JAK1, JAK2, JAK3, and TYK2) and ACVR1. - ZG005 works by blocking both the PD-1 and TIGIT immune checkpoints, aiming to synergistically activate T cells and enhance anti-tumor immune responses. - Gecacitinib inhibits the JAK-STAT pathway and ACVR1, reducing inflammation, improving anemia by downregulating hepcidin, improving iron metabolism, and reducing splenomegaly. - Both drugs are under clinical development by Suzhou Zelgen Biopharmaceuticals, primarily for oncological and hematological indications such as advanced solid tumors and myelofibrosis[1][2][4][5][6].
- Brand names
- Nilvanstomig
- Other names
- ZG005 + jaktinib
02
Targets
JAK1 (Janus kinase 1)JAK2 (Janus kinase 2)PDCD1 (Programmed cell death protein 1 receptor)TIGIT (T cell immunoreceptor with Ig and ITIM domains)ACVR1 (Activin receptor type I)JAK3 (Janus kinase 3)TYK2 (Tyrosine kinase 2)
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