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Topical Benzocaine Prior to Lidocaine for IUD Insertion Pain
NCT06951191Phase 4
Key facts
- Status
- Terminated
- Start
- Jun 2025
- Primary completion
- Apr 2026
- Countries
- 1
- Sponsor
- University of Missouri
- Modality
- Small Molecules
01
Overview
Phase 4, randomised, double-blind trial of benzocaine and lidocaine 10% oropharyngeal spray (4 arms), sponsored by University of Missouri. Primary endpoint: Mean Pain Score During IUD Insertion Events as Quantified by Visual Analogue Scale. Started Jun 2025; status: terminated.
02
Design
4 arms- Study design
- RandomizedDouble-blind
Placebo/Placebo
Saline spray and sham injection
Placebo/Lidocaine
Saline spray and lidocaine injection
Benzocaine/Placebo
Benzocaine spray and sham injection
Benzocaine/Lidocaine
Benzocaine spray and lidocaine injection
03
Who it enrols
Women 18 years or older undergoing IUD insertion, excluding those <6 weeks postpartum, with allergies to study drugs, undergoing general anesthesia, or using anti-inflammatory/anxiety medications in the 12 hours prior.
04
Endpoints
Primary
Mean Pain Score During IUD Insertion Events as Quantified by Visual Analogue Scale
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