Drug intelligence / Profile preview

amisulpride + cyclophosphamide + paroxetine + prednisone

Development stage
Unknown
Lead developer
Sanofi
Modality
Small Molecules
Administration
Oral, Intravenous
01

Overview

This is a combination of four pharmaceutical agents, each with distinct mechanisms and primary indications: - **Amisulpride** is an atypical antipsychotic and antiemetic that acts as a selective dopamine D2 and D3 receptor antagonist. It is used primarily for the treatment of schizophrenia (acute and chronic) and for the prevention/treatment of postoperative nausea and vomiting. Amisulpride preferentially targets dopamine receptors in the limbic system, reducing both positive and negative symptoms of schizophrenia while minimizing extrapyramidal side effects[4][5][7]. - **Cyclophosphamide** is an alkylating agent used mainly as a chemotherapeutic drug in various cancers (such as lymphomas, leukemias, breast cancer) and as an immunosuppressant in autoimmune diseases. It works by cross-linking DNA strands to inhibit cell replication. - **Paroxetine** is a selective serotonin reuptake inhibitor (SSRI) antidepressant indicated for major depressive disorder, anxiety disorders, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder (PTSD), among others. It increases synaptic serotonin levels by inhibiting its reuptake into presynaptic neurons. - **Prednisone** is a synthetic glucocorticoid corticosteroid with potent anti-inflammatory and immunosuppressive properties. It is widely used to treat inflammatory conditions such as asthma, rheumatoid arthritis, allergic reactions, certain cancers (as part of chemotherapy regimens), autoimmune diseases, among others. There are no known fixed-dose or branded pharmaceutical products containing this exact combination; use together would be off-label or investigational.

02

Targets

DRD3 (Dopamine receptor D3)GR (Glucocorticoid receptor)DRD2 (Dopamine D2 Receptor)SERT (Sodium-dependent serotonin transporter)

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