Drug intelligence / Profile preview

hydroxychloroquine + mycophenolate mofetil + prednisolone + tacrolimus

Development stage
Preclinical
Lead developer
Sanofi
Modality
Small Molecules
Administration
Oral, Intravenous
01

Overview

A combination of four immunomodulatory/immunosuppressive medications used for treating severe autoimmune conditions. The combination includes: - **Hydroxychloroquine**: A disease-modifying anti-rheumatic drug (DMARD) that suppresses Toll-like receptor activation and modulates immune system activity - **Mycophenolate mofetil**: An immunosuppressant that inhibits purine synthesis in lymphocytes - **Prednisolone**: A corticosteroid with broad anti-inflammatory and immunosuppressive effects - **Tacrolimus**: A potent calcineurin inhibitor that prevents T-cell activation and proliferation This combination provides multi-pathway immunosuppression and may be used in severe autoimmune conditions or complex cases requiring significant immune system modulation.

02

Targets

GR (Glucocorticoid receptor)IMPDH (Inosine-5'-monophosphate dehydrogenase 1)CN (Calcineurin)

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