Drug intelligence / Profile preview

amlodipine + levofloxacin + prednisone + propranolol + ramipril + thiamazole

Development stage
Unknown
Lead developer
Pfizer
Modality
Small Molecules
Administration
Oral, Intravenous, Ophthalmic
01

Overview

This is a combination of six active pharmaceutical ingredients, each with distinct mechanisms and indications:

  • Amlodipine is a dihydropyridine calcium channel blocker used primarily for hypertension and angina. It inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle, resulting in vasodilation.
  • Levofloxacin is a third-generation fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, leading to inhibition of bacterial replication. It is used to treat various infections including respiratory tract, urinary tract, skin, and soft tissue infections.
  • Prednisone is a synthetic glucocorticoid corticosteroid with anti-inflammatory and immunosuppressive properties. It modulates gene expression after binding to the glucocorticoid receptor.
  • Propranolol is a non-selective beta adrenergic antagonist (beta blocker) that reduces heart rate, myocardial contractility, blood pressure, and has antiarrhythmic effects.
  • Ramipril is an angiotensin-converting enzyme (ACE) inhibitor used for hypertension and heart failure; it blocks the conversion of angiotensin I to angiotensin II.
  • Thiamazole (also known as methimazole) is an antithyroid agent that inhibits thyroid hormone synthesis by blocking the oxidation of iodine in the thyroid gland.

This combination does not correspond to any approved fixed-dose product or unique brand name; it represents concurrent use of these drugs.

02

Targets

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