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camrelizumab + rh-endostatin
- Development stage
- Unknown
- Lead developer
- Hengrui Pharmaceutical
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
**camrelizumab + rh-endostatin** is a combination therapy for advanced non-small cell lung cancer (NSCLC). Camrelizumab is an anti-PD-1 monoclonal antibody that blocks the PD-1/PD-L1 immune checkpoint, enhancing T-cell-mediated antitumor immunity. Rh-endostatin (recombinant human endostatin) is an antiangiogenic drug that inhibits tumor angiogenesis by targeting vascular endothelial cells, promoting vascular normalization and improving the tumor immune microenvironment. The combination has shown promising efficacy and safety in clinical studies for advanced NSCLC[2][3][5].
- Other names
- camrelizumab plus rh-endostatinrh-endostatin plus camrelizumab
02
Targets
FGF2PDCD1 (Programmed cell death protein 1 receptor)NCL (Nucleolin)VEGFA (Vascular endothelial growth factor A)VEGFR2 (Vascular endothelial growth factor receptor 2)FGFR1 (Fibroblast growth factor receptor 1)
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