Nuelin

Nuelin is a prescription bronchodilator containing theophylline anhydrous, a methylxanthine derivative. It is indicated for the treatment and prophylaxis of reversible airway obstruction associated with asthma and chronic obstructive pulmonary disease (COPD). The drug's primary mechanism of action involves the non-selective inhibition of phosphodiesterase enzymes (specifically PDE III and PDE IV), which increases intracellular cyclic adenosine monophosphate (cAMP) levels, leading to smooth muscle relaxation in the bronchi. Additionally, theophylline acts as an adenosine receptor antagonist and may enhance histone deacetylase activity, contributing to its anti-inflammatory effects. Nuelin is marketed by iNova Pharmaceuticals and is available in various strengths and formulations, including sustained-release tablets designed for 12-hour or 24-hour dosing to maintain therapeutic serum concentrations.

Brand names

NuelinNuelin SRNuelin SA

Other names

theophyllinetheophylline anhydrous