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Mechanisms of Choroidal Blood Flow Changes
NCT00431392Phase 2
Key facts
- Status
- Completed
- Start
- Sep 2001
- Countries
- 1
- Sponsor
- Medical University of Vienna
- Modality
- Orthosteric Ligands
01
Overview
Phase 2, randomised trial of phenylephrine, NG-monomethyl-L-arginine, propranolol and atropine (4 arms), sponsored by Medical University of Vienna. Primary endpoints: choroidal blood flow and fundus pulsation amplitude. Started Sep 2001; status: completed.
02
Design
4 arms- Study design
- Randomized
Phenylephrine
Administration of Phenylephrine
L-NMMA
Administration of NG-Monomethyl-L-Arginine
Propranolol
Administration of Propranolol
Atropine
Administration of Atropine
03
Who it enrols
Healthy men aged 19-35, nonsmokers, with normal medical and ophthalmic findings. Exclusion criteria include regular medication use, alcohol abuse, and recent blood donation.
04
Endpoints
Primary
choroidal blood flow
fundus pulsation amplitude
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