Drug intelligence / Profile preview

anlotinib + carboplatin + cisplatin + pemetrexed

Development stage
Preclinical
Lead developer
Chia Tai-Tianqing Pharmaceutical Group
Modality
Small Molecules
Administration
Oral, Intravenous
01

Overview

A combination therapy consisting of anlotinib (a multi-target tyrosine kinase inhibitor that inhibits angiogenesis by targeting VEGFR, PDGFR, FGFR, and c-Kit), carboplatin (a platinum-based chemotherapy agent), cisplatin (a platinum-based chemotherapy agent), and pemetrexed (a folate analog that inhibits multiple enzymes involved in folate metabolism and DNA synthesis). This combination likely aims to leverage multiple mechanisms of action for enhanced anti-tumor efficacy in advanced cancers, particularly non-small cell lung cancer.

02

Targets

GART (GAR transformylase)FGFR (FGFR family)VEGFR2 (Vascular endothelial growth factor receptor 2)PDGFRB (Platelet-derived growth factor receptor beta)DHFR (Dihydrofolate reductase)VEGFR-1 (Vascular endothelial growth factor receptor 1)DNAVEGFR3 (Vascular endothelial growth factor receptor 3)EGFR T790M (Epidermal growth factor receptor T790M mutant)KIT (c-KIT proto-oncogene receptor tyrosine kinase)TS (Thymidylate synthase)

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